Coacervate Microparticles Useful for the Sustained Release Administration of...
Polymer matrix-based sustained-release formulations have gained significant interest in recent years for both parenteral and delivery of small molecules as well as proteins and other biological...
View ArticleNon-Invasive In Vivo MR Method to Image Salient Features of Nerves
The invention consists of a novel diffusion MRI experiment and modeling framework that describes white matter in the central nervous system (CNS) and nerves in the peripheral nervous system (PNS) as...
View ArticleFluorescent Primer(s) Creation for Nucleic Acid Detection and Amplification
CDC researchers have developed technology that consists of a simple and inexpensive technique for creating fluorescent labeled primers for nucleic acid amplification. Fluorescent chemical-labeled...
View ArticlePhotoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification
CDC scientists have developed a rapid and cost-efficient method for generating fluorescently labeled primers for PCR and real-time PCR. At present, fluorescent primers are useful for detecting and...
View ArticleAutomated Microscopic Image Acquisition, Compositing and Display Software...
Micro-Screen is a CDC developed software program designed to capture images and archive and display a compiled image(s) from a portion of a microscope slide in real time. This program allows for the...
View ArticleMethods of Retaining Methylation Pattern Information in Globally Amplified DNA
CDC researchers have developed a novel method that generates globally amplified DNA copies retaining parental methylation information; making accurate DNA-archiving for methylation studies much more...
View ArticleMonitoring the Effects of Sleep Deprivation Using Neuronal Avalanches
Investigators at the National Institute of Mental Health have discovered a novel method for monitoring the effects of sleep deprivation on brain activity. Sleep deprivation has been known to adversely...
View ArticleNovel Dopamine D2 Receptor Antagonists and Methods of Their Use
Investigators at the NIH have identified a series of novel, small molecule antagonists of the dopamine D2 receptor. Among the dopamine receptor (DAR) subtypes, D2 DAR is arguably one of the most...
View ArticleMagnetic Resonance Magnification Imaging
With conventional MRI, it is inherently time-consuming to generate high dimensional images with high spatial resolution. This invention, inspired by optical magnification, uses a fundamentally...
View ArticleA Mobile Health Platform
The NIH inventors have developed a mobile health technology to monitor and predict a user’s psychological status and to deliver an automated intervention when needed. The technology uses smartphones to...
View ArticleMethods of Making and Using Dopamine D3 Receptor Selective...
Dopamine is a major neurotransmitter in the central nervous system and among other functions is directly related to the rewarding effects of drugs of abuse. Dopamine signaling is mediated by D1, D2,...
View ArticleMADCO-Accelerated Multidimensional Diffusion MRI
Although multidimensional diffusion/relaxation NMR experiments are widely used in materials sciences and engineering applications, preclinical and clinical MRI applications of these techniques were not...
View ArticleNovel Magnetic Resonance Spectroscopy (MRS) Technique to Quantify Brain...
With respect to quantification of metabolites in the brain, conventional methods of magnetic resonance spectroscopy (MRS) yield results that are highly variable and highly dependent on the sequence...
View ArticleA Novel Reagent for Labeling PET Tracers at Trifluoromethyl Groups
The molecular imaging technique of positron emission tomography (PET) is an increasingly important tool in biomedical research and in drug discovery and development. Many small molecule drugs and...
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